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Poison damage can affect an Immortal through card abilities and match location properties.
When an Immortal is poisoned, a poison amount deals damage to the Immortal at the end of every turn. After dealing damage the poison amount is reduced by half until it reaches 0 and is removed.
"Why fight when you can watch the enemy’s last breaths from a safe distance?" - Shadow Handbook, Chapter 1 - Poisons and other “cowardly” tactics